Authors
Seunghyun Kim, Chunsik Bae, Daniel S. Oh, Taeho Ahn, Myung-Ho Han
Abstract
BACKGROUND: Recruitment and homing cells into graft materials from host tissue is crucial for bone regeneration.
METHODS: Highly porous, multi-level structural, hydroxyapatite bone void filler (HA-BVF) have been investigated to
restore critical size bone defects. The aim was to investigate a feasibility of bone regeneration of synthetic HA-BVF
compared to commercial xenograft (Bio-Oss). HA-BVF of 0.7 mm in average diameter was prepared via template coating
method. Groups of animals (n = 6) were divided into two with normal (Sham) or induced osteoporotic conditions (Ovx).
Subsequently, subdivided into three treated with HA-BVF as an experiment or Bio-Oss as a positive control or no treatment
as a negative control (defect). The new bone formation was analyzed by micro-CT and histology.
RESULTS: At 4 weeks post-surgery, new bone formation was initiated from all groups. At 8 weeks post-surgery, new
bone formation in the HA-BVF groups was greater than Bio-Oss groups. Extraordinarily greater bone regeneration within
the Ovx-HA group than Sham–Bio-Oss or Ovx–Bio-Oss group (p\0.05).
CONCLUSION: This study suggests that the immediate wicking property of HA-BVF from host tissue activates a natural
healing cascade without the addition of exogeneous factors or progenitor cells. HA-BVF may be an effective alternative for
repairing bone defects under both normal and osteoporotic bone conditions.
Publication
The Korean Tissue Engineering and Regenerative Medicine Society; July 2018