Publications
Publications
Reconstruction of Segmental Bone Defect in Canine Tibia Model Utilizing Bi-Phasic Scaffold: Pilot Study
The reunion and restoration of large segmental bone defects pose significant clinical challenges. Conventional strategies primarily involve the combination of bone scaffolds with seeded cells and/or growth factors to regulate osteogenesis and angiogenesis.
WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects
Treating osteoporosis and associated bone fractures remains challenging for drug development in part due to potential off-target side effects and the requirement for long-term treatment.
Multiple Porous Synthetic Bone Graft Comprising Engineered Micro-Channel for Drug Carrier and Bone Regeneration
Due to high demand but limited supply, there has been an increase in the need to replace autologous bone grafts with alternatives that fulfill osteogenic requirements.
Wicking Property of Graft Material Enhanced Bone Regeneration in the Ovariectomized Rat Model
This study suggests that the immediate wicking property of HA-BVF from host tissue activates a natural healing cascade without the addition of exogeneous factors or progenitor cells.
Capillary action: enrichment of retention and habitation of cells via microchanneled scaffolds for massive bone defect regeneration
The development of a biomaterial substitute that can promote bone regeneration in massive defects has remained as a significant clinical challenge even using bone marrow cells or growth factors.
Effects of capillary action on bone regeneration in micro-channeled ceramic scaffolds
A new scaffold design was introduced with macro-pores and micro-channels, which greatly assisted in the initial bone marrow absorption and uniform cell distribution.
Bone marrow absorption and retention properties of engineered scaffolds with micro-channels and nano-pores for tissue engineering: A proof of concept
We have developed a hydroxyapatite-based scaffold with micro-channels and nano-pores (MCNP) using a polyurethane template coating method to overcome some of the limitations by addressing fluid absorbance and retention via capillary action.
Porous hydroxyapatite scaffold with three-dimensional localized drug delivery system using biodegradable microspheres
In this study, ionic immobilization of dexamethasone (DEX)-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres was performed on the hydroxyapatite (HAp) scaffold surfaces.